反应 #833511

反应方程式

3-Methoxy-4-(2-propenyloxy)benzaldehyde

sodium hydroxide

mesitylene

→

3-allyl-4-hydroxy-5-methoxybenzaldehyde

反应条件

后处理

1. 1
   温度After cooling
2. 2
   洗涤The aqueous phase was washed two times with diethyl ether
3. 3
   萃取extracted with ethyl acetate
4. 4
   其他After drying
5. 5
   浓缩concentrating the organic phase, there
6. 6
   其他that crystallized
7. 7
   温度on cooling

实验过程

3-Methoxy-4-(2-propenyloxy)benzaldehyde (19.7 g, 0.100 mol) was heated under reflux in 75 ml mesitylene (1,3,5-trimethylbenzene) for 20 hours. After cooling, 250 ml 2N sodium hydroxide were added to the reaction mixture. The aqueous phase was washed two times with diethyl ether. The aqueous phase was subsequently acidified with concentrated hydrochloric acid under ice cooling and then extracted with ethyl acetate. After drying and concentrating the organic phase, there remained a light orange-colored oil that crystallized on cooling.

来源