反应 #83236

反应方程式

5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole

1,1-dicyano-2-ethoxyethylene

→

7-amino-6-cyano-2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine

收率 59.3%

溶剂

acetic acid

反应条件

后处理

1. 1
   温度was refluxed for 1 hour
2. 2
   浓缩The reaction mixture was concentrated in vacuo
3. 3
   其他the residue was crystallized from ethanol

实验过程

A mixture of 5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole (100 mg) and 1,1-dicyano-2-ethoxyethylene (49 mg) in acetic acid (2 ml) was refluxed for 1 hour. The reaction mixture was concentrated in vacuo and the residue was crystallized from ethanol to give 7-amino-6-cyano-2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine (77 mg).

来源