反应 #83201

反应方程式

HCl

diethyl carbonate

sodium ethoxide

6H-pyrido[3,2,1-de]acridin-1(2H)-one

→

Ethyl 6H-pyrido[3,2,1-de]acridin-1(2H)-one

溶剂

ethanol

反应条件

后处理

1. 1
   温度the solution was then refluxed for 3 hours
2. 2
   温度The reaction mixture was cooled
3. 3
   萃取extracted with methylene chloride
4. 4
   萃取The organic extract
5. 5
   洗涤was washed with water
6. 6
   其他was then collected
7. 7
   其他dried
8. 8
   其他evaporated to dryness
9. 9
   其他to obtain a light amber solid (1.8 g; m.p. 113°-118° C.)

实验过程

To a freshly prepared solution of sodium ethoxide in ethanol (from 0.35 g sodium metal and 10 ml ethanol) was added 6H-pyrido[3,2,1-de]acridin-1(2H)-one (1.2 g) portionwise over a period of 10 minutes. To the resulting dark red solution was slowly added diethyl carbonate (1.77 g) and the solution was then refluxed for 3 hours. The reaction mixture was cooled, acidified to pH 2 with concentrated HCl and then extracted with methylene chloride. The organic extract was washed with water and was then collected, dried and evaporated to dryness to obtain a light amber solid (1.8 g; m.p. 113°-118° C.).

来源