反应 #83175

反应方程式

D-glucono1,5-lactone

tallowaminopropylamine

→

D-gluconamide

溶剂

methanol

反应条件

后处理

1. 1
   其他A 1 liter round bottom flask equipped with a condenser, addition funnel
2. 2
   其他the heating mantle removed
3. 3
   温度The reaction mixture was cooled
4. 4
   过滤The white product was filtered
5. 5
   洗涤washed with cold isopropanol (3×100ml)
6. 6
   其他dried under vacuum at 35° C.

实验过程

A 1 liter round bottom flask equipped with a condenser, addition funnel, thermometer and mechanical stirrer was charged with D-glucono1,5-lactone (20.0 g, 0.11 mole) and methanol (56 g). The suspension was heated to 40° C. over 15 minutes and the heating mantle removed. Hydrogenated tallowaminopropylamine (36.0 g, 0.11 mole) was added dropwise over 15 minutes with rapid stirring. The reaction mixture was cooled and placed in a refrigerator at 0° C. overnight. The white product was filtered, washed with cold isopropanol (3×100ml) and dried under vacuum at 35° C. giving 46.2 g (83% yield) of hydrogenated tallowaminopropyl D-gluconamide with a melting point of 112°-115° C.

来源