反应 #83054

反应方程式

DL-2-aminopimelic acid

tetrahydrofuran

phosgene

→

desired product

2,5-Dioxo-4-oxazolidinepentanoic acid

溶剂

toluene

反应条件

后处理

1. 1
   其他Argon is bubbled through the reaction
2. 2
   其他to remove the excess phosgene
3. 3
   其他the solvents are removed under house vacuum
4. 4
   workup.DISSOLUTIONThe resulting oil is dissolved in 14 ml of ethyl alcohol
5. 5
   workup.ADDITIONdiluted with 14 ml of petroleum ether
6. 6
   其他The formed crystals are collected
7. 7
   其他dried

实验过程

A suspension of 1.752 g of DL-2-aminopimelic acid, 55 ml of tetrahydrofuran and 16 ml of 1.93M phosgene in toluene is heated, in an oil bath, at 50° C. for 1 hour. Argon is bubbled through the reaction to remove the excess phosgene and the solvents are removed under house vacuum. The resulting oil is dissolved in 14 ml of ethyl alcohol, diluted with 14 ml of petroleum ether and the solution stored overnight at room temperature. The formed crystals are collected and dried to give 1.6 g of the desired product.

来源