反应 #82742

反应方程式

cyanogen bromide

4-isopropylaniline

→

4-isopropylphenyl cyanamide

收率 84.0%

溶剂

diethylether

diethylether

反应条件

后处理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe reaction mixture was kept stirring at room temperature for 18 h
3. 3
   其他Then a solution with white precipitates
4. 4
   其他formed
5. 5
   其他the precipitates were removed by filtration
6. 6
   洗涤The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine
7. 7
   干燥dried over MgSO4
8. 8
   过滤filtered
9. 9
   浓缩concentrated
10. 10
    其他dried under vacuum

实验过程

A solution of cyanogen bromide (1.59 g, 15 mmol) in diethylether (20) was added dropwise to a solution of 4-isopropylaniline (3.24 g) in diethylether (50 mL) at 4° C. with stirring. After the addition, the reaction mixture was kept stirring at room temperature for 18 h. Then a solution with white precipitates formed and the precipitates were removed by filtration. The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine, dried over MgSO4, filtered, concentrated, and dried under vacuum to yield 4-isopropylphenyl cyanamide (2.0 g, 84%).

来源