反应 #82698

反应方程式

2-methoxy-thioacetamide

1,3-dichloroacetone

→

4-Chloromethyl-2-methoxymethyl-1,3-thiazole

溶剂

ethanol

反应条件

后处理

1. 1
   其他The solvent was evaporated
2. 2
   萃取After extraction with ether the organic phase
3. 3
   洗涤was washed twice with water
4. 4
   干燥dried over sodium sulfate
5. 5
   其他Evaporation of the solvent
6. 6
   workup.WAITleft 13.0 g crude product

实验过程

A solution of 9 g of 2-methoxy-thioacetamide and 10.87 g 1,3-dichloroacetone in 90 ml ethanol was refluxed for 2 h. The solvent was evaporated and the residue neutralized with saturated sodium bicarbonate solution. After extraction with ether the organic phase was washed twice with water and dried over sodium sulfate. Evaporation of the solvent left 13.0 g crude product.

来源