反应 #82516

反应方程式

N-benzyloxycarbonyl 3(S)-amino-1,2-(S)-epoxy-4-phenylbutane

isoamylamine

→

N[3(S)-benzyloxycarbonylamino-2(R)-hydroxy-4-phenylbutyl]N-isoamylamine

收率 81.0%

溶剂

isopropyl alcohol

反应条件

后处理

1. 1
   温度to reflux for 2.5 hours
2. 2
   浓缩concentrated in vacuo
3. 3
   其他recrystallized
4. 4
   其他The product was isolated by filtration and from ethylacetate/hexane

实验过程

A solution of N-benzyloxycarbonyl 3(S)-amino-1,2-(S)-epoxy-4-phenylbutane (30.1 g, 0.10 mol) and 165 mL isoamylamine in 150 mL of isopropyl alcohol was heated to reflux for 2.5 hours. The solution was cooled to room temperature, concentrated in vacuo and then recrystallized. The product was isolated by filtration and from ethylacetate/hexane to afford 31.7 g (81%) of N[3(S)-benzyloxycarbonylamino-2(R)-hydroxy-4-phenylbutyl]N-isoamylamine.

来源