反应 #82386

反应方程式

N2 [3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-4(S)-hydroxy-L-prolinamide

→

N2 [3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-4(S)-hydroxy-L-prolinamide

收率 98.6%

溶剂

ethanol

反应条件

后处理

1. 1
   过滤The catalyst was filtered off
2. 2
   其他the filtrate was evaporated

实验过程

0.11 g of N2 -[3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-4(S)-hydroxy-L-prolinamide was dissolved in 10 ml of ethanol and hydrogenated over 20 mg of 10% palladium-on-carbon at room temperature and under atmospheric pressure for 2 hours. The catalyst was filtered off and the filtrate was evaporated to give 0.08 g of N2 -[3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1 -tert.butyl-4(S)-hydroxy-L-prolinamide as a gum which was used without further purification.

来源