反应 #820499

反应方程式

HCl

EDC HOBT

(S)-2-hydroxy-propylamine

pyrrolidine-1,2(S)-dicarboxylic acid 1-t-butyl ester

→

(S)-Pyrrolidine-2-carboxylic acid ((S)-2-hydroxy-propyl)-amide hydrochloride

溶剂

dioxane

反应条件

实验过程

Compound I6 was prepared by EDC/HOBT-coupling of (S)-2-hydroxy-propylamine with pyrrolidine-1,2(S)-dicarboxylic acid 1-t-butyl ester (analogous to Step A of Example I4), followed by HCl-cleavage in dioxane (Step B of Example I5). The crude salt was used as such.

来源