反应 #8198

反应方程式

3-Methylbenzo[b]thiophene

n-bromosuccinimide

2,2′Azobisisobutyronitrile

→

3-Bromomethylbenzo[b]thiophene

收率 42.2%

溶剂

carbon tetrachloride

反应条件

后处理

1. 1
   温度the resulting mixture is refluxed for two hours
2. 2
   温度After cooling
3. 3
   过滤the reaction mixture is filtered through a glass-fritted funnel
4. 4
   浓缩the filtrate is concentrated
5. 5
   其他The residue is triturated with petroleum ether and toluene

实验过程

3-Methylbenzo[b]thiophene (9.9 g, 67 mmol) is heated in carbon tetrachloride (133 ml ) to near reflux in the presence of n-bromosuccinimide (11.9 g, 67 mmol, 1.0 eq.). 2,2′Azobisisobutyronitrile (2.2 g, 13.3 mmol, 0.2 eq.) is added and the resulting mixture is refluxed for two hours. After cooling, the reaction mixture is filtered through a glass-fritted funnel, and the filtrate is concentrated. The residue is triturated with petroleum ether and toluene to afford 6.42 g of 3-Bromomethylbenzo[b]thiophene (42%).

来源