反应 #81887

反应方程式

3-(t-butyloxycarbonylamino)-1-propylamine

triethylamine

p-methoxybenzyl bromoacetate

→

p-methoxybenzyl [3-(t-butyloxycarbonylamino)-1-propylamino]acetate

收率 40.0%

溶剂

CH2Cl2

CH2Cl2

反应条件

后处理

1. 1
   洗涤The mixture was washed with water and saturated sodium chloride solution
2. 2
   干燥dried over anhydrous sodium sulfate
3. 3
   过滤filtered
4. 4
   浓缩concentrated in vacuo
5. 5
   其他to give a dark residue
6. 6
   其他The crude material was purified by column chromatography on silica gel (elution with 50% ethyl acetate/hexane)

实验过程

To a cold (0°-5° C.) solution of 3-(t-butyloxycarbonylamino)-1-propylamine (4.00 g, 23 mmol) and triethylamine (2.8 mL, 20 mmol) in anhydrous CH2Cl2 (15 mL) was added slowly a solution of p-methoxybenzyl bromoacetate (5.18 g, 20 mmol) in anhydrous CH2Cl2 (10 mL) over a period of 2.5 h. The mixture was stirred at 0°-5° C. for 2 h, at which time TLC indicated that the reaction was complete. The mixture was washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give a dark residue. The crude material was purified by column chromatography on silica gel (elution with 50% ethyl acetate/hexane) to afford 2.81 g (40% yield) of p-methoxybenzyl [3-(t-butyloxycarbonylamino)-1-propylamino]acetate as an amber oil. 1H NMR (300 MHz, CDCl3) δ1.41 (s, 9H), 1.61 (quint, J=7 Hz, 2H), 2.63 (t, J=7 Hz, 2H), 3.17 (q, J=6 Hz, 2H), 3.38 (s, 2H), 3.78 (s, 3H), 5.07 (s, 2H), 6.86 (m, 2H), and 7.26 (m, 2H); IR (film), 1736, 1708 cm-1 ; MS (isobutane-DCI) MH+ =353. Anal. Calcd. for C18H28N2O5 : C, 61.35; H, 8.01; N, 7.95. Found: C, 60.87; H, 8.30; N, 7.89.

来源