反应 #816394

反应方程式

phytantriol

acetone

→

2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-6,10,14-trimethyl-pentadecan-2-ol

反应条件

后处理

1. 1
   其他for 15 hr
2. 2
   其他After the completion of the reaction
3. 3
   其他the acetone solvent was removed under reduced pressure
4. 4
   萃取the resultant was extracted with chloroform solution
5. 5
   洗涤The extract was washed with saturated sodium bicarbonate solution
6. 6
   洗涤was again washed with saline

实验过程

One g of phytantriol (3.0 mmol, Sigma-Aldrich) was refluxed using deanstock apparatus for 15 hr in 25 ml of acetone solution with toluene sulfonic acid as catalyst. After the completion of the reaction, the acetone solvent was removed under reduced pressure and the resultant was extracted with chloroform solution. The extract was washed with saturated sodium bicarbonate solution and was again washed with saline to obtain 0.3 g of (2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-6,10,14-trimethyl-pentadecan-2-ol) of which 1- and 2-positions were protected.

来源