反应 #816386
ord-7edc6e62b38842c4962ead419202b6d3
反应方程式
KCN
benzoyl chloride
water methylene chloride
benzo(f)chinolin
→
3-cyano-4-benzoyl-3,4-dihydrobenzo(f)chinoline
反应条件
详细条件
See reaction.notes.procedure_details.
后处理
- 1其他The organic phase was separated
- 2洗涤washed with water, 5% hydrochloric acid, water, 5% NaOH solution
- 3干燥After drying over magnesium sulfate
- 4其他the solution was evaporated to dryness
实验过程
648 μl (5.58 mmol) benzoyl chloride was added to a two phase system of water/methylene chloride over a period of two hours. These two layers contain 500 mg (2.79 mmol) of benzo(f)chinolin in the methylene chloride layer and 545 mg (8.37 mmol) KCN in water. Stirring was continued for 6 hours. The organic phase was separated and washed with water, 5% hydrochloric acid, water, 5% NaOH solution, and again with water. After drying over magnesium sulfate, the solution was evaporated to dryness.