反应 #8147

反应方程式

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

n-butylamine

→

2-n-butylamino-4-(3-diethylamino-1-propoxy)nitrobenzene

溶剂

THF

反应条件

后处理

1. 1
   其他After completion of the reaction
2. 2
   浓缩the reaction mixture is concentrated in vacuo
3. 3
   workup.DISSOLUTIONThe residue is redissolved in EtOAc (10 mL)
4. 4
   洗涤washed with saturated sodium bicarbonate solution, water, and brine
5. 5
   干燥The organic phase is then dried over sodium sulfate
6. 6
   其他the solvent is removed in vacuo

实验过程

A solution of 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene (2 mmol; preparation described in Example 5) in THF (5 mL) is treated with n-butylamine (2.4 eq) at rt. After completion of the reaction, the reaction mixture is concentrated in vacuo. The residue is redissolved in EtOAc (10 mL), washed with saturated sodium bicarbonate solution, water, and brine. The organic phase is then dried over sodium sulfate and the solvent is removed in vacuo to afford the product, 2-n-butylamino-4-(3-diethylamino-1-propoxy)nitrobenzene (580 mg) which was used for further transformation without further purification.

来源