反应 #814024

反应方程式

Phosgene

4-bromo-2-fluorobenzylamine

hydrochloric acid

4-bromo-2-fluorobenzylamine hydrochloride

→

4-bromo-2-fluorobenzyl isocyanate

收率 92.1%

溶剂

toluene

反应条件

后处理

1. 1
   温度the mixture is then refluxed
2. 2
   其他to remove the gases phosgene and hydrogen chloride
3. 3
   workup.DISTILLATIONThe batch is worked up by distillation

实验过程

A solution of 4-bromo-2-fluorobenzylamine (20.4 g, 0.10 mol) in toluene (300 ml) is saturated with gaseous hydrochloric acid at 25° C. The resulting suspension of the 4-bromo-2-fluorobenzylamine hydrochloride is heated at 100° C. Phosgene is passed in at this temperature. Stirring of the solution, which has eventually become clear, is continued at 100° C. for 1 hour, and the mixture is then refluxed to remove the gases phosgene and hydrogen chloride. The batch is worked up by distillation. 21.2 g of 4-bromo-2-fluorobenzyl isocyanate (boiling point 109° C. at 4 mbar) are obtained. Yield: 92.1% of theory.

来源