反应 #81377

反应方程式

4-formylphenol

1-bromooctane

potassium carbonate

→

desired compound

4-octyloxybenzaldehyde

溶剂

acetone

反应条件

后处理

1. 1
   温度was refluxed overnight
2. 2
   其他the reaction was quenched by the addition of 100 ml of water
3. 3
   萃取The desired compound was extracted from the reaction mixture
4. 4
   干燥The resultant solution was dried over magnesium sulfate
5. 5
   过滤filtered
6. 6
   浓缩concentrated in vacuo
7. 7
   其他to provide a liquid which
8. 8
   其他was purified

实验过程

A solution containing 3.053 g (25 mmol) of 4-formylphenol, 6.48 ml (3705 mmol) of 1-bromooctane and 6.9 mg (50 mmol) of potassium carbonate in 100 ml of acetone was refluxed overnight. When the reaction was substantially complete, as indicated by thin layer chromatagraphy (TLC), the reaction was quenched by the addition of 100 ml of water. The desired compound was extracted from the reaction mixture using two 100 ml portions of diethyl ether. The resultant solution was dried over magnesium sulfate, filtered and then concentrated in vacuo to provide a liquid which was purified using HPLC (eluent of 10 ethyl acetate in hexane) to provide the desired compound.

来源