反应 #81242

反应方程式

ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

4'-bromomethylbiphenyl-2-carbonitrile

potassium t-butoxide

→

title compound

收率 95.3%

Ethyl 1-(2'-cyanobiphenyl-4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

收率 95.3%

反应条件

实验过程

Following a procedure similar to that as described in Example 68(a), but using 4.01 g of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (prepared as described in Preparation 9), 5.0 g of 4'-bromomethylbiphenyl-2-carbonitrile and 1.97 g of potassium t-butoxide, 6.86 g of the title compound were obtained as crystals, melting at 92°-93° C.

来源