反应 #811386

反应方程式

N-ethyldiisopropylamine

6-bromo-2-naphthoic acid

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

cyclobutylamine

1-hydroxy-1H-benzotriazole monohydrate

→

title compound

收率 72.7%

6-bromo-N-cyclobutyl-2-naphthamide

收率 72.7%

溶剂

dimethylformamide

反应条件

实验过程

By reactions similar to those in Reference Example 2, using 6-bromo-2-naphthoic acid (1.01 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.92 g), 1-hydroxy-1H-benzotriazole monohydrate (0.735 g; HOBt), dimethylformamide (16 ml), N-ethyldiisopropylamine (0.62 g) and cyclobutylamine (0.45 g), the title compound (0.89 g) was obtained as colorless needle crystals.

来源