反应 #80941

反应方程式

hydrochloric acid

2-bromo-4-chloro-5-formylphenol

sodium hydroxide

hydrogen peroxide

→

2-bromo-4-chlorocatechol

反应条件

后处理

1. 1
   workup.ADDITIONUpon completion of addition
2. 2
   过滤The mixture was then filtered
3. 3
   其他to collect a solid
4. 4
   洗涤The solid was washed with water
5. 5
   其他dried under vacuum

实验过程

A stirred solution of 25.0 grams (0.106 mole) of 2-bromo-4-chloro-5-formylphenol in 106 mL (0.106 mole) of aqueous 1N sodium hydroxide was warmed to about 50° C., and 150 mL (0.133 mole) of aqueous 3% hydrogen peroxide was added dropwise. Upon completion of addition, the reaction mixture was allowed to cool to ambient temperature as it stirred for about 18 hours. After this time, the reaction mixture was made acidic with aqueous 6N hydrochloric acid. The mixture was then filtered to collect a solid. The solid was washed with water and dried under vacuum, yielding 21.2 grams of 2-bromo-4-chlorocatechol. The NMR spectrum was consistent with the proposed structure.

来源