反应 #80935

反应方程式

2-amino-6-methylbenzonitrile

chloroformamidine hydrochloride

→

2,4-diamino-5-methylquinazoline

收率 86.9%

溶剂

2-methoxyethyl ether

反应条件

后处理

1. 1
   其他This compound was prepared in a manner analogous to that of Step E of Example 1

实验过程

This compound was prepared in a manner analogous to that of Step E of Example 1, using 10.0 grams (0.076 mole) of 2-amino-6-methylbenzonitrile (prepared as in Example 1, Step B), and 10.0 grams (0.087 mole) of chloroformamidine hydrochloride in 40 mL of 2-methoxyethyl ether, yielding 11.5 grams of 2,4-diamino-5-methylquinazoline. The NMR spectrum was consistent with the proposed structure.

来源