反应 #80905

反应方程式

2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile

chloroformamidine hydrochloride

→

2,4-diamino-5-chloro-6-(3,5-dichlorophenyl)quinazoline

收率 29.4%

溶剂

2-methoxyethyl ether

反应条件

后处理

1. 1
   其他This compound was prepared in a manner analogous to that of Step E of Example 1
2. 2
   其他The solid was recrystallized from methanol

实验过程

This compound was prepared in a manner analogous to that of Step E of Example 1, using 1.5 grams (0.005 mole) of 2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile and 0.7 gram (0.006 mole) of chloroformamidine hydrochloride in 10 mL of 2-methoxyethyl ether. The solid was recrystallized from methanol, yielding 0.5 gram of 2,4-diamino-5-chloro-6-(3,5-dichlorophenyl)quinazoline. The NMR spectrum was consistent with the proposed structure; however, methanol was present in the sample.

来源