反应 #8069

ord-7f859e611fc340788dd94777d9e88e65

反应方程式

COC(=O)c1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
( 4 )
COC(=O)c1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
CCNCC
diethylamine
→
CCN(CC)Cc1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
title compound
CCN(CC)Cc1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
4-diethylaminomethyl-6-(2,4-difluorophenyl)-2-isobutyl-2H-pyridazin-3-one

反应物

COC(=O)c1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
( 4 )
COC(=O)c1cc(-c2ccc(F)cc2F)nn(CC(C)C)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methoxycarbonyl-2H-pyridazin-3-one
CC(C)Cn1nc(-c2ccc(F)cc2F)cc(COS(C)(=O)=O)c1=O
6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one
CCNCC
diethylamine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他were reacted

实验过程

Following the procedure of Example 9 (4), 6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and diethylamine were reacted to yield the title compound as a pale yellow oil (yield: quantitative).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07087606B2uspto-grants-2006_08