反应 #806301

反应方程式

vanillin

ethyl bromoacetate

potassium carbonate

→

(4-Formyl-2-methoxy-phenoxy)-acetic acid ethyl ester

溶剂

acetone

acetone

反应条件

后处理

1. 1
   温度were heated
2. 2
   温度to reflux for 3 hours
3. 3
   其他to come to rt
4. 4
   其他the residue partitioned between water and ethyl acetate
5. 5
   洗涤The ethyl acetate was washed with brine
6. 6
   干燥dried over magnesium sulfate
7. 7
   浓缩The organic layer was concentrated
8. 8
   其他the solid triturated with hexanes
9. 9
   其他to yield 28.4 grams of example No

实验过程

A flask containing vanillin (20 g, 0.13 mol), ethyl bromoacetate (28.4 g, 0.17 mol) and potassium carbonate (32.7 g, 0.24 mol) and acetone 200 mL were heated to reflux for 3 hours. The reaction was allowed to come to rt. The acetone was stripped off and the residue partitioned between water and ethyl acetate. The ethyl acetate was washed with brine and dried over magnesium sulfate. The organic layer was concentrated and the solid triturated with hexanes to yield 28.4 grams of example No. 169.

来源