反应 #806286

反应方程式

(R)-N-Benzyloxycarbonyl-α-[N-(t-butoxycarbonylmethyl)carbamoyl]benzylamine

→

title compound

收率 99.0%

(R)-α-[N-(t-Butoxycarbonylmethyl)carbamoyl]benzylamine

收率 99.0%

溶剂

EtOH

toluene

反应条件

后处理

1. 1
   过滤The reaction mixture was filtered through diatomaceous earth
2. 2
   其他the solvents were evaporated

实验过程

(R)-N-Benzyloxycarbonyl-α-[N-(t-butoxycarbonylmethyl)carbamoyl]benzylamine (Method 4; 12.8 g, 32.2 mmol) was dissolved in EtOH (99%, 200 ml) and toluene (50 ml). Pd/C (10%, 0.65 g) was added and hydrogenation was performed at atmospheric pressure for 5.5 hours at room temperature. The reaction mixture was filtered through diatomaceous earth and the solvents were evaporated to give the title compound (8.4 g, 99%). NMR (600 MHz, CDCl3): 1.45 (s, 9H), 3.93 (m, 2H), 4.54 (s, 1H), 7.31–7.42 (m, 5H), 7.51 (brs, 1H).

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