反应 #805499

反应方程式

ammonium hydroxide

ethyl 2-amino-thiophene-3-carboxylate

chloroformamidine hydrochloride

dimethylsulfone

→

crude title compound

收率 71.0%

2-amino-thieno[2,3-d]pyrimidin-4-(3H)-one

收率 71.0%

溶剂

water

反应条件

后处理

1. 1
   温度After cooling down to room temperature
2. 2
   过滤The solid was filtered off
3. 3
   洗涤washed with water
4. 4
   其他dried

实验过程

A suspension of ethyl 2-amino-thiophene-3-carboxylate (0.4 g, 2.34 mmol), chloroformamidine hydrochloride (0.67 g, 5.84 mmol) and dimethylsulfone (0.53 g, 11.7 mmol) was heated at 130° C. for 30 minutes. After cooling down to room temperature, water (10 ml) was added and ammonium hydroxide was used to neutralize the suspension till pH=8. The solid was filtered off, washed with water and dried, yielding the crude title compound (71%, 277 mg). The crude residue was used as such for further reaction.

来源