反应 #80466

反应方程式

3-(4-fluorophenylmethyl)thiophene

CHCl3 methanol

N-iodosuccinimide

→

2-iodo-3-(4fluorophenylmethyl)thiophene

收率 95.2%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   萃取The organic phase was extracted with saturated aqueous NaHCO3 and brine
2. 2
   干燥dried over MgSO4
3. 3
   过滤filtered
4. 4
   浓缩concentrated in vacuo

实验过程

To a solution of 3-(4-fluorophenylmethyl)thiophene (1.16 g, 6.04 mmol) in 1:1 CHCl3 /methanol was added N-iodosuccinimide (1.70 g, 7.53 mmol). The reaction mixture was stirred for 3 hours, and then was diluted with CH2Cl2. The organic phase was extracted with saturated aqueous NaHCO3 and brine, dried over MgSO4, filtered, and concentrated in vacuo to give 1.83 g of 2-iodo-3-(4fluorophenylmethyl)thiophene which was used without further purification.

来源