反应 #803342

反应方程式

potassium sodium tartrate

diisobutylaluminum hydride toluene

5-phenyloxolane-2-one

methanol

→

5-phenyloxolan-2-ol

收率 96.8%

溶剂

toluene

反应条件

后处理

1. 1
   workup.STIRRINGThe thus obtained mixture was stirred for 1 hour
2. 2
   其他Thereafter, the water layer was removed
3. 3
   workup.DISTILLATIONthe solvent was then distilled away under reduced pressure

实验过程

4.1 mL of a 1.5 mol/L diisobutylaluminum hydride/toluene solution was added dropwise to a solution of 1.0 g of 5-phenyloxolane-2-one in 12 mL of toluene at −60° C., and the obtained mixture was then stirred for 30 minutes. Thereafter, 1 mL of methanol was added to the reaction mixture, and thereafter, 40 mL of a 20% potassium sodium tartrate aqueous solution was then added to the mixture at room temperature. The thus obtained mixture was stirred for 1 hour. Thereafter, the water layer was removed, and the solvent was then distilled away under reduced pressure, so as to obtain 0.98 g of 5-phenyloxolan-2-ol in the form of a colorless oily product.

来源