反应 #80261

反应方程式

Methyl 3-bromoadamantaneacetate

Aluminum trichloride

→

methyl 3-phenyl-1-adamantaneacetate

溶剂

benzene

反应条件

后处理

1. 1
   其他The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
2. 2
   其他The layers were separated
3. 3
   干燥the organic layer was dried over sodium sulfate
4. 4
   过滤filtered
5. 5
   其他evaporated in vacuo

实验过程

Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

来源