反应 #80062

反应方程式

ethyl 4-[4-(1-benzylamino-cyclopropyl)-phenylethynyl]-benzoate

Compound 111

ethyl 4-[4-(1-benzylamino-cyclopropyl)-phenylethynyl]-benzoate

NaOH

→

title compound

收率 50.1%

4-[4-(1-Benzylamino-cyclopropyl)-phenylethynyl]-benzoic acid

收率 50.1%

溶剂

ethanol

tetrahydrofuran

反应条件

实验过程

Using General Procedure I; a solution of ethyl 4-[4-(1-benzylamino-cyclopropyl)-phenylethynyl]-benzoate (Compound 111, 75.0 mg, 0.19 mmol) in ethanol (4 mL) and tetrahydrofuran (4 mL) was treated with NaOH (80.0 mg, 2.0 mmols, 2.0 mL of a 1N aqueous solution) and stirred overnight at room temperature. Work-up afforded 35.0 mg (50%) of the title compound as a colorless solid.

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