反应 #792194

反应方程式

furan-2-ylboronic acid

4-chloro-phenylboronic acid

4-bromo-1H-imidazole

4-bromo-1-(4-chlorophenyl)-1H-imidazole

→

1-(4-chlorophenyl)-4-(furan-2-yl)-1H-imidazole

收率 12.0%

反应条件

实验过程

The procedure described above for Formula Ic-iii in Example 16 was followed, starting from 4-chloro-phenylboronic acid and 4-bromo-1H-imidazole, to prepare 4-bromo-1-(4-chlorophenyl)-1H-imidazole, which was then reacted with furan-2-ylboronic acid to prepare the desired 1-(4-chlorophenyl)-4-(furan-2-yl)-1H-imidazole (15 mg, 0.061 mmol, yield 12%) as an off-white solid. The HPLC purity of the final product was 95.45%. LC-MS [M+H] 245 (C13H9ClN2O+H expected 245.04). The 1H-NMR spectra was in accordance with the chemical structure.

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