反应 #792184

反应方程式

2-bromofuran

diisopropylamine

THF

trimethylsilyl acetylene

→

(furan-2-ylethynyl)trimethylsilane

收率 35.8%

溶剂

water

反应条件

后处理

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   萃取extracted with dichloromethane
3. 3
   洗涤The combined organic layers were washed with brine
4. 4
   干燥dried over anhydrous sodium sulfate
5. 5
   其他the solvent was evaporated
6. 6
   其他The crude material was purified by column chromatography (100-200 mesh silica gel)

实验过程

A mixture of 2-bromofuran (500 mg, 3.402 mmol), Pd(PPh3)2Cl2 (75.69 mg, 0.10784 mmol), CuI (40.17 mg, 0.2109 mmol) and diisopropylamine (0.89 ml, 6.395 mmol) in tetrahydrofuaran (THF) (4 ml) was degassed thoroughly with argon, and trimethylsilyl acetylene (0.648 ml, 4.694 mmol) was added at room temperature. After stirring the reaction mixture for 16 hours at room temperature, it was poured into water and extracted with dichloromethane. The combined organic layers were washed with brine and dried over anhydrous sodium sulfate and the solvent was evaporated. The crude material was purified by column chromatography (100-200 mesh silica gel) using hexane as eluent to yield the desired (furan-2-ylethynyl)trimethylsilane (200 mg, 1.21 mmol, yield 35.84%).

来源