反应 #792145

反应方程式

(E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one

→

final compound

收率 84.7%

1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridine-2-yl)propan-1-one

收率 84.7%

溶剂

EtOAc

反应条件

后处理

1. 1
   其他was conducted at atmospheric pressure room temperature until the starting material
2. 2
   过滤The catalyst was filtered
3. 3
   其他the crude was purified by chromatography on silica gel (25% EtOAc/hexane)

实验过程

In a 200 mL round-bottomed flask, (E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1.08 g, 3.63 mmol) and 80 mg of 10% Pd/C was mixed together in wet EtOAc (50 ml). Hydrogenation was conducted at atmospheric pressure room temperature until the starting material was gone. The catalyst was filtered and the crude was purified by chromatography on silica gel (25% EtOAc/hexane) to provide 0.92 g of final compound (82%) as off white solid.

来源