反应 #792140

反应方程式

sodium hydroxide

triazole

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-ethyl-oxirane

N-methyl-2-pyrrolidon

ammonium chloride

→

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)butan-2-ol

反应条件

后处理

1. 1
   萃取the mixture extracted with MTBE
2. 2
   洗涤washed with an aqueous solution of lithium chloride
3. 3
   其他The crude residue was purified by recrystallization in diisopropylether

实验过程

To 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-ethyl-oxirane (216.0 g, 0.63 mol) dissolved in N-methyl-2-pyrrolidon (2 L) was added sodium hydroxide (62.87 g, 1.57 mol) and triazole (217.1 g, 3.14 mol) at room temperature. The mixture was then stirred for 12 hours at 140° C. A solution of ammonium chloride and ice water was then added, the mixture extracted with MTBE and washed with an aqueous solution of lithium chloride. The crude residue was purified by recrystallization in diisopropylether to give 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)butan-2-ol compound as a colorless solid (127.0 g, 51%; m.p.=140-142° C.).

来源