反应 #78855

反应方程式

2-chloropyrazine

Sodium hydride

1H-imidazole-4-carboxaldehyde

→

title compound

收率 99.4%

1-(2-pyrazinyl)-1H-imidazole-4-carboxaldehyde

收率 99.4%

溶剂

DMF

DMF

反应条件

后处理

1. 1
   温度to warm to RT
2. 2
   温度The resulting mixture was heated to 100° C. for 18 h
3. 3
   其他The solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
5. 5
   洗涤washed with water and brine
6. 6
   干燥dried (MgSO4)
7. 7
   浓缩concentrated

实验过程

Sodium hydride (60% in oil, 720 mg, 18.0 mmol) was added to a 0° C. solution of 1H-imidazole-4-carboxaldehyde (2.20 g, 18.0 mmol) in DMF (8 mL). After stirring for 20 min at 0° C., the mixture was allowed to warm to RT and a solution of 2-chloropyrazine (2.06 g, 17.9 mmol) in DMF (4 mL) was added. The resulting mixture was heated to 100° C. for 18 h. The solvent was evaporated, the residue was dissolved in ethyl acetate, washed with water and brine, dried (MgSO4), and concentrated to provide 3.10 g (86%) of the title compound. MS 175 (M+H)+

来源