反应 #7827

反应方程式

N-(2-hydroxyphenyl)-3-methoxy-4-methylbenzamide

p-toluenesulfonic acid monohydrate

→

2-(3-methoxy-4-methylphenyl)-1,3-benzoxazole

溶剂

toluene

反应条件

后处理

1. 1
   温度was refluxed overnight
2. 2
   温度After cooling
3. 3
   其他reaction to rt
4. 4
   过滤filtered
5. 5
   洗涤washing with warm chloroform and concentrated filtrate in vacuo
6. 6
   其他The resulting brown oil was purified by flash chromatography on silica gel using 1:4 EtOAc

实验过程

A mixture of N-(2-hydroxyphenyl)-3-methoxy-4-methylbenzamide (1.5 g, 5.8 mmol), toluene (30 mL), p-toluenesulfonic acid monohydrate (7.6 g, 40 mmol) and molecular sieves was refluxed overnight. After cooling reaction to rt, filtered washing with warm chloroform and concentrated filtrate in vacuo. The resulting brown oil was purified by flash chromatography on silica gel using 1:4 EtOAc:hexanes to give the desired intermediate, 2-(3-methoxy-4-methylphenyl)-1,3-benzoxazole, as a colorless solid.

来源