反应 #78193

反应方程式

3-chloro-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine

para-methylaniline

→

Title compound

3-(4-methylanilino)-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine

溶剂

CH2Cl Methanol

methanol

反应条件

实验过程

The compound is prepared from 0.070 g 3-chloro-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine and 0.129 g para-methylaniline in the manner described in Example 82A. Title compound is obtained after FC in CH2Cl/Methanol 19/1; m.p. 68-70° C. 1H-NMR (250 MHz, CDCl3): δ=8.45 (s, wide, 2H); 7.45 (d, 2H); 7.10 (“d”, wide, 4H); 6.10 (s, wide, 1H); 4.25 (s, 2H); 2.30 (s, 3H); 2.15 (s, 3H); 2.10 (s, 3H). ES-MS 305 (M+H).

来源