反应 #76964

ord-25f7000c566c4da48ff68105d591bde0

反应方程式

COc1ccc(CC2NCCc3cc(OC)c(OC(C)C)cc32)cc1OC
1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
NCc1ccccc1
benzylamine
→
COc1ccc(CC2c3cc(OC(C)C)c(OC)cc3CCN2CC(=O)NCc2ccccc2)cc1OC
2-[1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-benzyl-acetamide

反应物

COc1ccc(CC2NCCc3cc(OC)c(OC(C)C)cc32)cc1OC
1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
NCc1ccccc1
benzylamine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-6-methoxy-7-isopropoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with benzylamine

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06703392B2uspto-grants-2004_03