反应 #76880

ord-c903b646e22e4f1d955c02fb3b8d7eb9

反应方程式

COc1cc2c(cc1OC)C(Cc1ccccc1)NCC2
1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
Cc1ccccc1CN
2-methylbenzylamine
→
COc1cc2c(cc1OC)C(Cc1ccccc1)N(CC(=O)NCc1ccccc1C)CC2
2-(1-Benzyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(2-methyl-benzyl)-acetamide

反应物

COc1cc2c(cc1OC)C(Cc1ccccc1)NCC2
1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
O=C(Br)CBr
2-bromoacetyl bromide
Cc1ccccc1CN
2-methylbenzylamine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

prepared by reaction of 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-methylbenzylamine

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06703392B2uspto-grants-2004_03