反应 #76776

反应方程式

sodium acetate

1,1-dibromo-3,3,3-trifluoroacetone

2-fluoro-4-chloro-5-hydroxyphenylhydrazine hydrochloride

→

3,3,3-trifluoro-2-oxopropanal 1-(4-chloro-2-fluoro-5-hydroxyphenylhydrazone)

收率 82.9%

溶剂

water

反应条件

后处理

1. 1
   温度the solution was heated at 80° to 90° C. for 40 minutes
2. 2
   其他obtained
3. 3
   workup.ADDITIONabove was added
4. 4
   过滤The precipitated crystals were collected by filtration
5. 5
   其他dried under reduced pressure, which

实验过程

Then, 49.2 g of sodium acetate and 40.5 g of 1,1-dibromo-3,3,3-trifluoroacetone were dissolved in 400 ml of water, and the solution was heated at 80° to 90° C. for 40 minutes. The solution was cooled to 0° C., to which 75 g of the crude 2-fluoro-4-chloro-5-hydroxyphenylhydrazine hydrochloride crystals obtained above was added, and the mixture was stirred at room temperature for 70 minutes. The precipitated crystals were collected by filtration and dried under reduced pressure, which afforded 35.4 g of 3,3,3-trifluoro-2-oxopropanal 1-(4-chloro-2-fluoro-5-hydroxyphenylhydrazone).

来源