反应 #76601

反应方程式

cinnamyl bromide

thiosalicylic acid

→

2-styrylsulfanylbenzoic acid

收率 102.2%

溶剂

ethanol

sodium hydroxide

反应条件

后处理

1. 1
   其他the solvent then removed under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   workup.ADDITIONconcentrated hydrochloric acid was added
4. 4
   过滤The resultant solid was filtered off
5. 5
   其他dried

实验过程

To a solution of 1.28 g (6.49 mmol) of cinnamyl bromide in 8 ml of ethanol at room temperature under an atmosphere of nitrogen was added a solution of 1 g (6.49 mmol) of thiosalicylic acid in 5.3 ml of 10% aqueous sodium hydroxide solution. The solution was stirred at room temperature for 16 hours and the solvent then removed under reduced pressure. The residue was dissolved in water and concentrated hydrochloric acid was added. The resultant solid was filtered off and dried. There was obtained 1.7 g of 2-styrylsulfanylbenzoic acid as a white solid, MS: m/e 270 M+.

来源