反应 #76540

反应方程式

N-(2-ethylthiazolo[4,5-c]quinolin-4-yl)trichloroacetamide

ammonia

→

2-ethylthiazolo[4,5-c]quinolin-4-amine

溶剂

methanol

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated under vacuum
2. 2
   洗涤The residue was washed with water
3. 3
   其他dried
4. 4
   其他to provide 0.19 g of crude product which
5. 5
   其他was recrystallized from ethyl acetate/hexane

实验过程

N-(2-ethylthiazolo[4,5-c]quinolin-4-yl)trichloroacetamide (0.40 g) was suspended in a solution of ammonia in methanol (20 mL of 2M) and then stirred at ambient temperature for 30 minutes. The reaction mixture was concentrated under vacuum. The residue was washed with water and then dried to provide 0.19 g of crude product which was recrystallized from ethyl acetate/hexane to provide 2-ethylthiazolo[4,5-c]quinolin-4-amine as tan needles, m.p. 170-172° C. Analysis: Calculated for C12H11N3S: %C, 62.85; %H, 4.83; %N, 18.32; Found: %C, 62.58; %H, 4.78; %N, 18.08.

来源