反应 #76016

反应方程式

tert-butyl (1S)-1-benzyl-2-hydroxypropylcarbamate

→

(3S)-3-amino-4-phenyl-2-butanol

收率 87.2%

溶剂

dioxane

dioxane

反应条件

实验过程

The process is performed as in Example 3, starting with 17.6 g of tert-butyl (1S)-1-benzyl-2-hydroxypropylcarbamate in 145 cm3 of dioxane and 61 cm3 of 6.5N hydrochloric dioxane, stirring for 16 hours at a temperature in the region of 20° C. After an identical work-up, 9.56 g of (3S)-3-amino-4-phenyl-2-butanol are obtained in the form of an orange-colored oil as a mixture of the two diastereoisomers (80/20). (Rf=0.25 in a 40/5/0.5 by volume mixture of dichloromethane/methanol/aqueous ammonia, on a Merck 60F254R silica plate).

来源