反应 #7601

反应方程式

4-chloro-7-(2-methoxyethoxy)cinnoline

2-fluoro-5-hydroxy-4-methylaniline

hydrogen chloride

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-7-(2-methoxyethoxy)cinnoline hydrochloride

收率 84.0%

溶剂

2-pentanol

反应条件

后处理

1. 1
   过滤The solid was filtered off
2. 2
   洗涤washed with isopropanol
3. 3
   干燥ether and dried under vacuum

实验过程

A solution of 4-chloro-7-(2-methoxyethoxy)cinnoline (156 mg, 0.65 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (111 mg, 0.78 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (8 ml) and 5M isopropanolic hydrogen chloride (1 ml) was heated at 120° C. for 2.5 hours. The solid was filtered off, washed with isopropanol and then ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-7-(2-methoxyethoxy)cinnoline hydrochloride (207 mg, 84%).

来源