反应 #7598

反应方程式

4,6-dichlorocinnoline

2-fluoro-5-hydroxy-4-methylaniline

→

6-chloro-4-(2-fluoro-5-hydroxy-4-methylanilino)cinnoline hydrochloride

收率 95.8%

溶剂

2-pentanol

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux for 45 minutes
3. 3
   温度After cooling the solid
4. 4
   过滤was filtered off
5. 5
   洗涤washed with isopropanol

实验过程

A solution of 4,6-dichlorocinnoline (200 mg, 1 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (169 mg, 1.2 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (4 ml) containing 7M isopropanolic hydrogen chloride (2 drops) was heated at reflux for 45 minutes. After cooling the solid was filtered off, washed with isopropanol followed by ether to give 6-chloro-4-(2-fluoro-5-hydroxy-4-methylanilino)cinnoline hydrochloride (326 mg, 95%).

来源