反应 #7597

反应方程式

4-chloro-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline

2-fluoro-5-hydroxy-4-methylaniline

hydrogen chloride

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline

溶剂

2-pentanol

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux for 45 minutes
3. 3
   温度After cooling the solid
4. 4
   过滤was filtered off
5. 5
   洗涤washed with isopropanol

实验过程

A solution of 4-chloro-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline (130 mg, 0.41 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (70 mg, 0.5 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (3 ml) containing 5M hydrogen chloride in isopropanol (2 drops) was heated at reflux for 45 minutes. After cooling the solid was filtered off, washed with isopropanol followed by ether to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline as an hydrochloride salt (159 mg, 88%).

来源