反应 #75873

反应方程式

L-Alanine ethyl ester

MgSO4

pivalaldehyde

→

N-neopentylidene-L-alanine ethyl ester

溶剂

CH2Cl2

反应条件

后处理

1. 1
   温度to warm to room temperature
2. 2
   过滤The reaction mixture was filtered
3. 3
   其他the filtrate was evaporated

实验过程

Step-2. L-Alanine ethyl ester from step-1 (9 g) was dissolved in 150 ml anhydrous CH2Cl2. The solution was cooled to 0° C. MgSO4 (10.17 g) was added to the solution followed by addition of pivalaldehyde (6.95 g). The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was filtered and the filtrate was evaporated to give 11.2 g of N-neopentylidene-L-alanine ethyl ester. The product was used for next step without further purification. MS: 186 (MH+).

来源