反应 #7577

反应方程式

sodium hydroxide

4-fluoro-2-methyl-5-nitrophenol

→

2-fluoro-5-hydroxy-4-methylaniline

收率 47.0%

溶剂

water

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux for 4 hours
3. 3
   温度to cool
4. 4
   萃取extracted with ethyl acetate (100 ml)
5. 5
   萃取The ethyl acetate extract
6. 6
   干燥was dried (MgSO4)
7. 7
   其他the solvent removed by evaporation

实验过程

A mixture of 4-fluoro-2-methyl-5-nitrophenol (2.1 g, 13 mmol), iron powder (1 g, 18 mmol) and iron(II)sulphate (1.5 g, 10 mmol) in water (40 ml) was heated at reflux for 4 hours. The reaction mixture was allowed to cool, neutralised with 2M aqueous sodium hydroxide solution and extracted with ethyl acetate (100 ml). The ethyl acetate extract was dried (MgSO4) and the solvent removed by evaporation to give 2-fluoro-5-hydroxy-4-methylaniline (0.8 g, 47%) as a solid.

来源