反应 #75562

反应方程式

thiosalicylic acid

ethylenediamine

methanol

→

pure product

收率 53.1%

2-(4,5-Dihydro-1H-imidazol-2-yl)-benzenethiol

收率 53.1%

溶剂

1,2-dichlorobenzene

反应条件

后处理

1. 1
   温度The mixture was refluxed under nitrogen for 4 h
2. 2
   workup.WAITto stand at 22° C. over night
3. 3
   其他the resulting yellow crystalline solid collected
4. 4
   洗涤washed with ether

实验过程

To a suspension of 20.0 g (0.112 mol) of thiosalicylic acid in 200 mL of 1,2-dichlorobenzene was added 21.6 mL (0.323 mol) of ethylenediamine. The mixture was refluxed under nitrogen for 4 h then cooled to ca. 60° C. and 50 mL of methanol was added. The solution was allowed to stand at 22° C. over night and the resulting yellow crystalline solid collected and washed with ether to give 10.6 g of pure product.

来源