反应 #75438

反应方程式

5-methyl-4-hexenoic acid

diazomethane

→

title product

Methyl 5-methyl-4-hexenoate

溶剂

ether

ether

反应条件

后处理

1. 1
   其他The solvent was then evaporated under vacuum

实验过程

Freshly prepared diazomethane in ether was added to an ice-cooled solution of 5-methyl-4-hexenoic acid (4.5 g, 35.16 mmol) in ether (10 mL) until the solution became slightly yellow in color. The solvent was then evaporated under vacuum to afford the title product as a colorless liquid in near quantitative yield (4.90 g). This product was used in the next reaction step without further purification. 1H NMR (CDCl3) δ1.62 & 1.68[2s, 6H, C(CH3)2], 2.30[m, 4H, (CH2)2], 3.69(s, 3H, COOCH3) and 5.07(t, 1H, CH).

来源